Inventors Sayan Basu and Vivek Singh’s use of stem cells in patented new therapy to treat vision loss

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Dr Vivek Singh (Left) and Dr Sayan Basu (Right)
Dr Vivek Singh (Left) and Dr Sayan Basu (Right)
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Patent for novel stem cell therapy to LVPEI 

Inventors Sayan Basu and Vivek Singh use stem cells from the eye’s surface to produce a patented new therapy to treat vision loss due to corneal scarring or corneal distention.

Hyderabad, 31 December 2023: The L V Prasad Eye Institute (LVPEI), Hyderabad has been granted a patent for a novel cell therapy that can be used to repair damaged corneas from a variety of corneal diseases. The patented therapy uses a unique composition of stem cells derived from the eye’s surface and two clotting factors, layered together. This patent has been granted by the Patent Office, Government of India, for a period of 20 years in accordance with the provisions of the Patents Act, 1970.

The patent was granted to two inventors from LVPEI, Drs Sayan Basu and Vivek Singh. Dr Basu is a corneal surgeon and a clinician-scientist at LVPEI. He is the Prof. D Balasubramanian Chair of Eye Research at the Brien Holden Eye Research Centre (BHERC); and the Director of the Centre for Ocular Regeneration (CORE) at LVPEI. Dr Vivek Singh is a scientist at the Sudhakar and Sreekanth Ravi Stem Cell Biology Laboratory and Centre for Ocular Regeneration (CORE), LVPEI.

Corneal scarring happens when the cornea (the transparent, outer layer of the eye) is damaged and turns opaque due to infection or accidents. Corneal blindness is a major cause of blindness and vision impairment, especially in low- and middle-income countries. Most forms of corneal blindness currently require corneal transplants, which are complex and require lifelong management. This patented composition has the potential to offer a viable alternative to transplants that uses either the person’s own, or donor corneal stem cells to repopulate the corneal surface with healthy, clear cells.

‘The potential impact of this patent extends beyond just scientific research to meet the needs of the broader public,’ says Dr Sayan Basu. ‘If the clinical trials are successful, this cell-based therapy could revolutionize the treatment of various corneal pathologies.’

Another example of the therapy’s potential impact is in treating Keratoconus, a chronic condition where the cornea thins out and changes shape, distorting vision. By deploying this patented therapy, there is potential to replenish corneal collagen, the connective protein that holds the shape of the cornea. Replenished collagen as a result of this technique can result in a strengthened cornea, offering a potential treatment to keratoconus.

‘This patent is testament to the world-class research that is rooted in India, and in solving India’s—and the world’s—burden due to corneal disease. This therapy has the potential to improve lives and I hope to see this become a reality soon,’ says Dr Vivek Singh.

Currently, under clinical trials, this unique ‘cell composition’ based therapy marks a significant milestone in the field of ophthalmology and cell-based therapy.

Editor’s notes

Patent details

·       Patent no.: 464537

·       The patent covers a specific combination of a set of stem cells unique to the cornea (stromal and epithelial stem cells)

·       These stem cells are layered and interlaced with the clotting proteins, thrombin and fibrinogen.

·       Stromal and epithelial stem cells are unipotent stem cells located on the rim of the cornea (on edge of the ‘black’ part of the eye). They can differentiate into a variety of corneal cells, repairing and remodelling the cornea.Press Release2a.jpg

About LVPEI: Established in 1987, L V Prasad Eye Institute (LVPEI), a World Health Organization Collaborating Centre for Prevention of Blindness, is a comprehensive eye health facility. The Institute has ten functional arms to its areas of operations: Clinical Services, Education, Research, Vision Rehabilitation, Rural and Community Eye Health, Eye Banking, Advocacy and Policy Planning, Capacity Building, Innovation, and Product Development. The LVPEI Eye Care Network has 290 Centres spread across Telangana, Andhra Pradesh, Odisha, and Karnataka in India. The institute’s mission is to provide equitable and quality eye care to all sections of society. The LVPEI’s five-tier ‘Eye Health Pyramid’ model, covering all areas of the community right from the villages to the city, provides high quality and comprehensive – prevention, curative, and rehabilitation – eye care to all. It has served over 36.89 million (3 crores 68 lakh people), with more than 50% entirely free of cost, irrespective of the complexity of care needed.

About Post Author

Editor Desk

Antara Tripathy M.Sc., B.Ed. by qualification and bring 15 years of media reporting experience.. Coverred many illustarted events like, G20, ICC,MCCI,British High Commission, Bangladesh etc. She took over from the founder Editor of IBG NEWS Suman Munshi (15/Mar/2012- 09/Aug/2018 and October 2020 to 13 June 2023).
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